Abstract |
Lysine vasopressin (1 microgram/rat SC) administered 1 hr prior to either the acquisition trial or 24 hr retention trial facilitated passive avoidance retention. Amnesia was produced when a single 50 mg/kg (IP) injection of pentylenetetrazol was given immediately following the passive avoidance acquisition trial. A single injection of lysine vasopressin (1 microgram/rat SC) administered 1 hr prior to either the acquisition trial or 24 hr retention trial antagonized the amnesia.
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Authors | H B Bookin, W D Pfeifer |
Journal | Pharmacology, biochemistry, and behavior
(Pharmacol Biochem Behav)
Vol. 7
Issue 1
Pg. 51-4
(Jul 1977)
ISSN: 0091-3057 [Print] United States |
PMID | 561964
(Publication Type: Journal Article)
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Chemical References |
- Vasopressins
- Lypressin
- Pentylenetetrazole
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Topics |
- Amnesia
(physiopathology)
- Amnesia, Retrograde
(chemically induced, physiopathology)
- Animals
- Avoidance Learning
(drug effects)
- Humans
- Lypressin
(pharmacology)
- Male
- Memory
(drug effects)
- Pentylenetetrazole
(antagonists & inhibitors, pharmacology)
- Rats
- Seizures
(chemically induced, physiopathology)
- Time Factors
- Vasopressins
(analogs & derivatives)
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