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Effect of lysine vasopressin on pentylenetetrazol-induced retrograde amnesia in rats.

Abstract
Lysine vasopressin (1 microgram/rat SC) administered 1 hr prior to either the acquisition trial or 24 hr retention trial facilitated passive avoidance retention. Amnesia was produced when a single 50 mg/kg (IP) injection of pentylenetetrazol was given immediately following the passive avoidance acquisition trial. A single injection of lysine vasopressin (1 microgram/rat SC) administered 1 hr prior to either the acquisition trial or 24 hr retention trial antagonized the amnesia.
AuthorsH B Bookin, W D Pfeifer
JournalPharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 7 Issue 1 Pg. 51-4 (Jul 1977) ISSN: 0091-3057 [Print] United States
PMID561964 (Publication Type: Journal Article)
Chemical References
  • Vasopressins
  • Lypressin
  • Pentylenetetrazole
Topics
  • Amnesia (physiopathology)
  • Amnesia, Retrograde (chemically induced, physiopathology)
  • Animals
  • Avoidance Learning (drug effects)
  • Humans
  • Lypressin (pharmacology)
  • Male
  • Memory (drug effects)
  • Pentylenetetrazole (antagonists & inhibitors, pharmacology)
  • Rats
  • Seizures (chemically induced, physiopathology)
  • Time Factors
  • Vasopressins (analogs & derivatives)

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