[Effect of ethyl alcohol on oxidation-reduction processes in the myocardium].

Abstract

Evidence is given of disturbances of aerobic oxidative process in the myocardial mitochondria occurring in acute and chronic alcoholic intoxication. A single introduction of alcohol in a dose of 1 and 3 g/kg to rats and dogs produces "hypoxyform" changes in the myocardium, viz. a fall of PO2, a reduced activity of most NAD-independent enzymes, activation of succinate- and lactate-dehydrogenases in a moderate dissociation of oxidative phosphorylation reactions. The damaging effect of the alcohol persists for 24 hours after its one-time introduction. Following a 2-month long alcoholic intoxication there was seen a depressed respiratory activity of the mitochondria and of the study enzymes, except for cytochrome-C-oxidase. It is assumed that the cardiotoxic effect of alcohol is due to the damage of the energy-producing system of the mitochondria.

• Authors: V I Shishov, N G Novoselova, E I Maevskiĭ
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1977 Mar-Apr Vol. 40 Issue 2 Pg. 168-73 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie étilovogo spirta na okislitel'no-vosstanovitel'nye protsessy v miokarde
• PMID: 558113 (Publication Type: English Abstract, Journal Article)

Chemical References

• Oxidoreductases
• L-Lactate Dehydrogenase
• Succinate Dehydrogenase
• Glutamate Dehydrogenase
• Cytochrome Reductases

Topics

• Alcoholic Intoxication (metabolism)
• Animals
• Cytochrome Reductases (metabolism)
• Glutamate Dehydrogenase (metabolism)
• Humans
• L-Lactate Dehydrogenase (metabolism)
• Male
• Mitochondria (enzymology)
• Myocardium (enzymology, metabolism)
• Oxidative Phosphorylation
• Oxidoreductases (metabolism)
• Oxygen Consumption
• Rats
• Succinate Dehydrogenase (metabolism)