Single-dose therapy with streptomycin and sulfametopyrazine for bacteriuria during pregnancy.

Abstract

One hundred and sixty-three patients with bacteriuria in pregnancy were treated with a single dose of antibiotic. Four regimens were used: sulfadoxine (sulphormethoxine) 2 g., sulfametopyrazine 2 g., streptomycin 1 g., and a combination of sulfametopyrazine 2 g. and streptomycin 1 g. The highest cure rate of 77% was achieved with streptomycin and sulfametopyrazine. The long-acting sulphonamides alone gave a cure rate of 55% while streptomycin alone eradicated 43% of the infections. Despite the high cure rate with combined therapy bacterial resistance developed in some cases.

• Authors: J D Williams, E K Smith
• Journal: British medical journal (Br Med J) Vol. 4 Issue 5736 Pg. 651-3 (Dec 12 1970) ISSN: 0007-1447 [Print] England
• PMID: 5488382 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Sulfonamides
• Streptomycin

Topics

• Bacteriuria (drug therapy)
• Drug Resistance, Microbial
• Drug Synergism
• Female
• Humans
• Pregnancy
• Pregnancy Complications, Infectious (drug therapy)
• Streptomycin (administration & dosage)
• Sulfonamides (administration & dosage)