Abstract |
4-(p-Chlorophenylthio)butanol (W-2719) and its major acid metabolites W-2718 ( butyrate) and W-2683 ( acetate), when administered as drug-diet admixtures to male and female Sprague-Dawley rats for five weeks (approximately 200.0 mg/kg/day), induced a marked leukopenia. Effect on the primary and secondary immune responses to bovine serum albumin (BSA) immunization was that of suppression as evidenced by strikingly reduced passive hemagglutination serum titers.
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Authors | R D Sofia, G M Fukui, B J Ludwig |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 29
Issue 12
Pg. 1868-70
( 1979)
ISSN: 0004-4172 [Print] Germany |
PMID | 546425
(Publication Type: Journal Article)
|
Chemical References |
- Butanols
- Serum Albumin, Bovine
- 4-(p-chlorophenylthio)butanol
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Topics |
- Animals
- Butanols
(pharmacology)
- Cattle
- Female
- Hemagglutination Tests
- Immunity
(drug effects)
- Immunization
- Leukopenia
(chemically induced, immunology)
- Male
- Rats
- Serum Albumin, Bovine
(immunology)
- Sex Factors
- Time Factors
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