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Effects on the immune response of rats rendered leukopenic with 4-(p-chlorophenylthio)-butanol (W-2719) and its major metabolites.

Abstract
4-(p-Chlorophenylthio)butanol (W-2719) and its major acid metabolites W-2718 (butyrate) and W-2683 (acetate), when administered as drug-diet admixtures to male and female Sprague-Dawley rats for five weeks (approximately 200.0 mg/kg/day), induced a marked leukopenia. Effect on the primary and secondary immune responses to bovine serum albumin (BSA) immunization was that of suppression as evidenced by strikingly reduced passive hemagglutination serum titers.
AuthorsR D Sofia, G M Fukui, B J Ludwig
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 29 Issue 12 Pg. 1868-70 ( 1979) ISSN: 0004-4172 [Print] Germany
PMID546425 (Publication Type: Journal Article)
Chemical References
  • Butanols
  • Serum Albumin, Bovine
  • 4-(p-chlorophenylthio)butanol
Topics
  • Animals
  • Butanols (pharmacology)
  • Cattle
  • Female
  • Hemagglutination Tests
  • Immunity (drug effects)
  • Immunization
  • Leukopenia (chemically induced, immunology)
  • Male
  • Rats
  • Serum Albumin, Bovine (immunology)
  • Sex Factors
  • Time Factors

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