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Amantadine-dopamine interaction: possible mode of action in Parkinsonism.

Abstract
Intravenous doses of amantadine hydrochloride, an antiviral drug, as small as 0.08 milligram per kilogram may release dopamine and other catecholamines from neuronal storage sites in dogs primed with dopamine. This release may account for the reported efficacy of amantadine hydrochloride in the treatment of human parkinsonism.
AuthorsR P Grelak, R Clark, J M Stump, V G Vernier
JournalScience (New York, N.Y.) (Science) Vol. 169 Issue 3941 Pg. 203-4 (Jul 10 1970) ISSN: 0036-8075 [Print] United States
PMID5427356 (Publication Type: Journal Article)
Chemical References
  • Atropine
  • Amantadine
  • Acetylcholine
  • Dopamine
Topics
  • Acetylcholine (antagonists & inhibitors)
  • Amantadine (pharmacology, therapeutic use)
  • Animals
  • Atropine (pharmacology)
  • Dogs
  • Dopamine (metabolism, pharmacology)
  • Neurons (metabolism)
  • Parkinson Disease (drug therapy, physiopathology)
  • Stimulation, Chemical
  • Vagotomy

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