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[Ultrastructural study of Mibelli's porokeratosis. Pathogenic and therapeutic considerations in three cases].

Abstract
Report of three cases of porokeratosis Mibelli with emphasis on the ultrastructural changes of the entire epidermis underlying the cornoid lamella: autophagocytosis, filamentous degeneration, formation of "corps ronds". These phenomena are correlated with those of apoptosis (or intraepidermal cellular death with filamentous degeneration). Its role in the genesis of the cornoid lamella and in the degeneration of the lesions is discussed. In conclusion, on the basis of the reported observations and of the studies showing the action of retinoic acid and its derivatives on precancerous lesions, the authors propose to treat the actinic disseminated form of porokeratosis Mibelli with the aromatic derivative of retinoic acid (RO 10 9359).
AuthorsP Chavaz, P Carraux, P Laugier
JournalAnnales de dermatologie et de venereologie (Ann Dermatol Venereol) Vol. 106 Issue 8-9 Pg. 657-62 (Sep 1979) ISSN: 0151-9638 [Print] France
Vernacular TitleEtude ultrastructurale de la porokératose de Mibelli. Considérations pathogéniques et thérapeutiques à propos de trois cas.
PMID539705 (Publication Type: Case Reports, English Abstract, Journal Article)
Topics
  • Epidermis (ultrastructure)
  • Female
  • Humans
  • Keratosis (drug therapy, etiology)
  • Male

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