Abstract |
Since dicarboxylic acids are competitive inhibitors of tyrosinase, and effective in treatment of hyperpigmentary disorders, such as chloasma and lentigo maligna, probably due to a cytotoxic effect on abnormal melanocytes, it is of interest to examine their effect on normal melanocytes in tissue culture. Azelaic or dodecandioic acids were added (150-200 micrograms/ml) to dispersed cultures of epidermal cells, and melanocytes were examined by electron microscopy after 7, 10, 15, 20 and 30 days. Apart from a stimulation of melanogenesis, the presence of dicarboxylic acids in the culture medium caused no detectable damage to melanocytes, nor did they prevent growth of a second generation of cells.
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Authors | A S Breathnach, B Martin, M Nazzaro Porro, S Passi, P Mann, J Cooper, G Morpurgo |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 101
Issue 6
Pg. 641-9
(Dec 1979)
ISSN: 0007-0963 [Print] England |
PMID | 534609
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Culture Techniques
- Dicarboxylic Acids
(pharmacology)
- Epidermal Cells
- Epidermis
(drug effects)
- Humans
- Melanocytes
(drug effects, ultrastructure)
- Microscopy, Electron
- Mitosis
(drug effects)
- Time Factors
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