Abstract |
1 Labetalol was given to 41 hypertensive patients in a divided dosage of 150--2,400 mg daily for periods ranging from 1--64 months. 2 Monotherapy with labetalol was adequate in 12 out of 19 patients with essential hypertension and in 15 out of the 22 with renal hypertension. 3 Following a single dose of labetalol 200 mg orally a hypotensive response was seen between 1.5 and 2 hours. 4 In the doses used there was no exercise or postural hypotension. 5 No reduction in overall renal function attributable to labetalol was seen.
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Authors | F D Thompson, A M Joekes, M M Hussein |
Journal | British journal of clinical pharmacology
(Br J Clin Pharmacol)
Vol. 8
Issue Suppl 2
Pg. 129S-133S
( 1979)
ISSN: 0306-5251 [Print] England |
PMID | 526392
(Publication Type: Journal Article)
|
Chemical References |
- Ethanolamines
- Creatinine
- Labetalol
|
Topics |
- Blood Pressure
(drug effects)
- Creatinine
(blood)
- Dose-Response Relationship, Drug
- Ethanolamines
(therapeutic use)
- Humans
- Hypertension
(complications, drug therapy)
- Kidney Diseases
(complications)
- Labetalol
(adverse effects, therapeutic use)
- Physical Exertion
- Posture
- Pulse
(drug effects)
- Time Factors
|