Clinical evaluation of mezlocillin.

Abstract

The safety and efficacy of intravenous mezlocillin were determined in 25 patients with aerobic, anaerobic, and mixed infections. Included were pleuropulmonary, urinary tract, skin, and soft-tissue infections, osteomyelitis, and abdominal and breast abscess. Nineteen patients (76%) were cured without recurrence as determined by clinical and bacteriological parameters. In three, the infection recurred (12%); two patients failed (8%), and in one, it was indeterminate (4%). No serious adverse effects were noted except for severe thrombophlebitis in three (12%) patients. Our preliminary data suggest that mezlocillin is a safe (except for thrombophlebitis) and effective antibiotic in the treatment of aerobic anaerobic, and mixed infections.

• Authors: H Thadepalli, B Rao
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 16 Issue 5 Pg. 605-10 (Nov 1979) ISSN: 0066-4804 [Print] United States
• PMID: 526001 (Publication Type: Journal Article)

Chemical References

• Penicillins

Topics

• Abscess (drug therapy)
• Aerobiosis
• Anaerobiosis
• Bacterial Infections (drug therapy)
• Humans
• Osteomyelitis (drug therapy)
• Penicillins (adverse effects, therapeutic use)
• Pleurisy (drug therapy)
• Respiratory Tract Infections (drug therapy)
• Urinary Tract Infections (drug therapy)