Oesophageal neoplasia in male Wistar rats due to parenteral di(2-hydroxypropyl)-Nitrosamine (DHPN): a combined histopathological, histochemical and electron microscopic study.

Intraperitoneal di(2-hydroxypropyl)-Nitrosamine (DHPN) caused a high incidence of oesophageal squamous carcinoma in male Wistar rats, particularly in rats killed 11 or more months after the start of injections. No control rats (injected intraperitoneally with saline) developed an oesophageal neoplasms. Histopathologically, the tumours were moderately well differentiated. Histochemical studies showed minor increases in mucin staining and mast cell population and a marked increase in bacteria in tumour-bearing oesophaguses. Electron microscopy showed the tumours to be similar to, but to differ in some respects from squamous carcinomas at other sites in humans. The possible implications of this work for human disease are twofold. It could provide a model for further study of aspects of oesophageal carcinoma and it serves to remind us that all potential oesophageal carcinogens need not act during swallowing.
AuthorsD A Levison, D Hopwood, R G Morgan, G Coghill, G A Milne, K G Wormsley
JournalThe Journal of pathology (J Pathol) Vol. 129 Issue 1 Pg. 31-6 (Sep 1979) ISSN: 0022-3417 [Print] ENGLAND
PMID521868 (Publication Type: Journal Article)
Chemical References
  • Carcinogens
  • Mucins
  • Nitrosamines
  • Propylamines
  • Animals
  • Carcinogens
  • Carcinoma, Squamous Cell (analysis, chemically induced, ultrastructure)
  • Esophageal Neoplasms (analysis, chemically induced, ultrastructure)
  • Injections, Intraperitoneal
  • Male
  • Microscopy, Electron
  • Mucins (analysis)
  • Neoplasms, Experimental (analysis, chemically induced, ultrastructure)
  • Nitrosamines (administration & dosage)
  • Papilloma (analysis, chemically induced, ultrastructure)
  • Propylamines (administration & dosage)
  • Rats

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