An examination of the role of vitamin E in glucose-6-phosphate dehydrogenase deficiency.

Abstract

The effect of vitamin E on erythrocyte glutathione stability was studied both in vitro and in vivo on subjects with glucose-6-phosphate dehydrogenase deficiency. The results suggest that lipid membrane peroxidation in glucose-6-phosphate dehydrogenase deficient erythrocytes, which has been postulated to occur under conditions of oxidative stress, does not result in significant depletion of erythrocyte reduced glutathione pools. Vitamin E supplementation in these individuals was shown to have little or no effect on the response of their erythrocytes to oxidative stress.

• Authors: J G Newman, T B Newman, L J Bowie, J Mendelsohn
• Journal: Clinical biochemistry (Clin Biochem) Vol. 12 Issue 5 Pg. 149-51 (Oct 1979) ISSN: 0009-9120 [Print] United States
• PMID: 519843 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Vitamin E
• Glutathione

Topics

• Erythrocytes (drug effects)
• Glucosephosphate Dehydrogenase Deficiency (blood, drug therapy)
• Glutathione (blood)
• Humans
• Vitamin E (blood, pharmacology, therapeutic use)