Hypophagia follows the initial hyperphagia produced by 2-deoxy-D-glucose in rats.

Abstract

The glucose analogue 2-deoxy-D-glucose (2DG) inhibits glucose metabolism and causes a rapid increase in food consumption in most species. This increase is most apparent during the first 6 postinjection hours, although it may persist as long as 10 hr. There are no published descriptions of alterations in food consumption subsequent to the hyperphagia. In the present study male and female rats were injected with 2DG (750 mg/kg IP), insulin (regular, 20 U/kg SC) or distilled water, and food intake was compared to baseline levels during the next 1, 6 and 24 hr. Results showed that food intake: (1) was not affected by injections of water: (2) was higher than normal during all 3 time periods following insulin injections: and (3) was higher than normal at 1 and 6 hr following 2DG, but significantly lower than normal by the end of 24 hr. The reasons underlying the development of hypophagia subsequent to the initial hyperphagia produced by 2DG are presently unknown.

• Authors: C I Thompson, I S Zagon, P J McLaughlin
• Journal: Physiology & behavior (Physiol Behav) Vol. 23 Issue 1 Pg. 187-90 (Jul 1979) ISSN: 0031-9384 [Print] United States
• PMID: 515210 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Deoxy Sugars
• Insulin
• Deoxyglucose

Topics

• Animals
• Body Weight (drug effects)
• Deoxy Sugars (pharmacology)
• Deoxyglucose (pharmacology)
• Eating (drug effects)
• Female
• Insulin (pharmacology)
• Male
• Rats