Abstract |
Ethanol (6 g/kg/day) produced intrauterine growth retardation (both body weight and length) in rat fetuses compared to pair-fed controls. Associated with this retardation was an increase in fetal body water and sodium content and a decrease in lipid-free solid content. Comparable electrolyte changes were not observed in maternal blood. These effects in fetal body content are not commonly observed in fetal malnutrition studies and are suggestive of a direct teratogenic effect of ethanol.
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Authors | E L Abel, H B Greizerstein |
Journal | The Journal of pharmacology and experimental therapeutics
(J Pharmacol Exp Ther)
Vol. 211
Issue 3
Pg. 668-71
(Dec 1979)
ISSN: 0022-3565 [Print] United States |
PMID | 512929
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Body Weight
(drug effects)
- Electrolytes
(metabolism)
- Ethanol
(toxicity)
- Female
- Fetal Growth Retardation
(chemically induced)
- Fetus
(drug effects, metabolism)
- Organ Size
(drug effects)
- Placenta
(drug effects)
- Pregnancy
- Rats
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