Abstract |
Addition of 4 ppm Se to the drinking water of male albino rats fed diets containing 0.03% 2-acetylaminofluorene (AAF) provided protection against hepatic damage and also resulted in at least 50% reduction in liver tumor incidence. An in vitro assay system utilizing microsomes from Se supplemented or non-supplemented 3-methylcholanthrene (MC) induced rats was used to determine the effect of oral Se intake on the metabolism of AAF. Oral Se administration led to an increase in ring hydroxylation and a decrease in N-hydroxylation. Addition of Se to the microsomal assay system increased 3-OH AAF formation and decreased N- OH AAF formation, thus shifting the balance of metabolism toward detoxification pathways.
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Authors | M V Marshall, M S Arnott, M M Jacobs, A C Griffin |
Journal | Cancer letters
(Cancer Lett)
Vol. 7
Issue 6
Pg. 331-8
(Oct 1979)
ISSN: 0304-3835 [Print] Ireland |
PMID | 509411
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Hydroxyacetylaminofluorene
- Methylcholanthrene
- 2-Acetylaminofluorene
- Selenium
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Topics |
- 2-Acetylaminofluorene
(metabolism)
- Animals
- Biotransformation
(drug effects)
- Hydroxyacetylaminofluorene
(metabolism)
- In Vitro Techniques
- Liver
(drug effects)
- Liver Neoplasms, Experimental
(chemically induced, prevention & control)
- Male
- Methylcholanthrene
(pharmacology)
- Microsomes, Liver
(metabolism)
- Rats
- Selenium
(pharmacology)
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