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Selenium effects on the carcinogenicity and metabolism of 2-acetylaminofluorene.

Abstract
Addition of 4 ppm Se to the drinking water of male albino rats fed diets containing 0.03% 2-acetylaminofluorene (AAF) provided protection against hepatic damage and also resulted in at least 50% reduction in liver tumor incidence. An in vitro assay system utilizing microsomes from Se supplemented or non-supplemented 3-methylcholanthrene (MC) induced rats was used to determine the effect of oral Se intake on the metabolism of AAF. Oral Se administration led to an increase in ring hydroxylation and a decrease in N-hydroxylation. Addition of Se to the microsomal assay system increased 3-OH AAF formation and decreased N-OH AAF formation, thus shifting the balance of metabolism toward detoxification pathways.
AuthorsM V Marshall, M S Arnott, M M Jacobs, A C Griffin
JournalCancer letters (Cancer Lett) Vol. 7 Issue 6 Pg. 331-8 (Oct 1979) ISSN: 0304-3835 [Print] Ireland
PMID509411 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Hydroxyacetylaminofluorene
  • Methylcholanthrene
  • 2-Acetylaminofluorene
  • Selenium
Topics
  • 2-Acetylaminofluorene (metabolism)
  • Animals
  • Biotransformation (drug effects)
  • Hydroxyacetylaminofluorene (metabolism)
  • In Vitro Techniques
  • Liver (drug effects)
  • Liver Neoplasms, Experimental (chemically induced, prevention & control)
  • Male
  • Methylcholanthrene (pharmacology)
  • Microsomes, Liver (metabolism)
  • Rats
  • Selenium (pharmacology)

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