The effect of intravenous disopyramide phosphate on recurrent paroxysmal tachycardias.

Abstract

1 Reccurent paroxysmal atrial, atrioventricular and ventricular tachycardias in 50 patients without acute coronary insufficiency, heart failure or metabolic abnormlity were treated with disopyramide phosphate in a dose of 2 mg/kg body weight infused over 5 min. 2 Conversion to sinus rhythm within 10 min of the completed infusion occurred in 10 of 14 (71%) patients with paroxysmal 'lone' atrial fibrillation, 3 of 7 (43%) patients with paroxysmal atrial flutter, 6 of 9 (67%) patients with paroxysmal atrial tachycardia, 5 of 9 (56%) patients with paroxysmal atrioventricular tachycardia associated with the Wolff-Parkinson-White syndrome and 8 of 11 (73%) patients with paroxysmal ventricular tachycardia. 3 Side effects: significant systemic hypotension in 3, high grade AV block in 1, an increased ventricular response producing symptoms in 4, post conversion asystole in 1 land sinus bradycardia in 2. 4 The anti-arrhythmic effect and arrhythmogenic side effects may be related to both the direct membrane stabilizing effect and the anticholinergic effect of disopyramide.

• Authors: J Camm, D Ward, R A Spurrell
• Journal: British journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 8 Issue 5 Pg. 441-9 (Nov 1979) ISSN: 0306-5251 [Print] England
• PMID: 508548 (Publication Type: Journal Article)

Chemical References

• Pyridines
• Disopyramide

Topics

• Atrial Fibrillation (drug therapy)
• Atrial Flutter (drug therapy)
• Blood Pressure
• Disopyramide (administration & dosage, adverse effects, therapeutic use)
• Electrocardiography
• Humans
• Infusions, Parenteral
• Pyridines (therapeutic use)
• Recurrence
• Tachycardia, Paroxysmal (drug therapy, physiopathology)
• Time Factors