Haem biosynthesis studied in patients with rheumatoid arthritis.

Abstract

In a study of the urinary excretion of haem precursors in patients with rheumatoid arthritis, iron-deficiency anaemia, and in healthy controls, certain differences were found. In iron-deficiency anaemia the excretion of both porphobilinogen and delta-aminolevulinic acid was increased, whereas in patients with rheumatoid arthritis only the porphobilinogen excretion was increased.A further study on the erythrocyte activity of delta-aminolevulinic acid dehydrase showed a higher activity in the erythrocytes from patients with rheumatoid arthritis compared with healthy controls.

• Authors: S V Johansson, P O Strandberg
• Journal: Journal of clinical pathology (J Clin Pathol) Vol. 25 Issue 2 Pg. 159-62 (Feb 1972) ISSN: 0021-9746 [Print] England
• PMID: 5017445 (Publication Type: Journal Article)

Chemical References

• Levulinic Acids
• Porphyrins
• Pyrroles
• Heme
• Hydro-Lyases

Topics

• Anemia, Hypochromic (metabolism, urine)
• Arthritis, Rheumatoid (metabolism, urine)
• Erythrocytes (enzymology)
• Heme (biosynthesis, urine)
• Humans
• Hydro-Lyases (blood)
• Levulinic Acids (urine)
• Porphyrins (urine)
• Pyrroles (urine)