Effect of Triton WR-1339 on the rates of synthesis and degradation of hepatic catalase of rat.

Abstract

The effect of Triton WR-1339 on the rates of synthesis and degradation of hepatic catalase was examined. Triton WR-1339 was injected intraperitoneally into rats at a dose of 200 mg per 100 g body weight. Catalase activity decreased to about 35% of that of the control at 42-48 h after the injection and recovered to the normal level at 96 h. Other peroxisomal enzymes, D-amino acid oxidase and urate oxidase, showed similar patterns of the activities to those of catalase. During the first 48 h after the injection of Triton WR-1339, the rate of catalase synthesis (ks) fell to below a detectable value, while that of the degradation (kd) did not show any significant change. On the other hand, during the period 48-96 h after the injection, the rate of the synthesis (ks) returned to the normal level though that of the degradation (kd) decreased to about 50% of the control.

• Authors: H Ishii, T Suga, H Hayashi, S Niinobe
• Journal: Journal of biochemistry (J Biochem) Vol. 86 Issue 4 Pg. 1163-6 (Oct 1979) ISSN: 0021-924X [Print] England
• PMID: 500584 (Publication Type: Journal Article)

Chemical References

• Polyethylene Glycols
• Catalase
• Amitrole

Topics

• Amitrole (pharmacology)
• Animals
• Catalase (biosynthesis, metabolism)
• Kinetics
• Liver (drug effects, enzymology)
• Male
• Polyethylene Glycols (pharmacology)
• Rats