A retrospective evaluation of nifedipine therapy in Prinzmetal's angina.

Abstract

A retrosepctive evaluation has been made of blood pressure, pulse rate, and number of anginal attacks per day in twenty-one patients diagnosed as Prinzmetal's Angina and treated with the investigational drug nifedipine. The effect of combining nifedipine with short- and long-acting nitrates or with propranolol was also evaluated. In consideration of the statisically significant reduction in the number of anginal attacks per day, p less than 0.001, together with the non-significant mean changes in blood pressure and pulse rate as well as the compatibility with the other drugs, it is concluded that nifedipine is a very useful drug, in a dose range of 30--120 mg per day, for the treatment of Prinzmetal's Angina. Recorded side-effects were of minimal severity and in no case caused nifedipine therapy to be discontinued.

• Authors: R Battye, C M Ordille
• Journal: The Journal of international medical research (J Int Med Res) Vol. 7 Issue 5 Pg. 360-9 ( 1979) ISSN: 0300-0605 [Print] England
• PMID: 499644 (Publication Type: Journal Article)

Chemical References

• Pyridines
• Vasodilator Agents
• Nifedipine

Topics

• Adult
• Angina Pectoris (drug therapy)
• Angina Pectoris, Variant (drug therapy)
• Blood Pressure (drug effects)
• Drug Evaluation
• Female
• Humans
• Male
• Middle Aged
• Nifedipine (therapeutic use)
• Pulse (drug effects)
• Pyridines (therapeutic use)
• Retrospective Studies
• Vasodilator Agents (therapeutic use)