[Results of the use of a new aminoglycoside antibiotic, sisomicin, in gram negative bacterial respiratory infections].

Abstract

Clinical efficacy of a new aminoglycoside antibiotic, sisomicin, was evaluated in 14 patients with acute chest infections (12 cases with pneumonia and 2 with bronchitis). They were selected taking into account the isolation of sisomicin-sensitive Gram-negative bacilli in a sputum specimen collected prior to therapy. Local predisposing factors were present in 4 patients whereas general predisposing factors were present in 4 patients whereas general predisposing factors were recognizable in 9. Klebsiella was isolated in 5 cases, E. coli in 5 cases, Proteus in 4 cases, P. aeruginosa in 2 cases, Ct-trobacter and Providencia each in one. In all patients the bacteriological finding was negative after the cycle of therapy; clinical outcome was uniformly favourable (11 patients healed, 3 got better). No significant adverse effects due to the antibiotic was noted.

• Authors: A Lechi, E Arosio, C Mengoli, G Montesi, D Bonato
• Journal: Minerva medica (Minerva Med) Vol. 70 Issue 41 Pg. 2821-5 (Sep 26 1979) ISSN: 0026-4806 [Print] Italy
• Vernacular Title: Risultati dell'impiego di un nuovo antibiotico aminoglicosidico, la sisomicina, nella infezioni respiratorie da batteri gram-negativi.
• PMID: 492551 (Publication Type: English Abstract, Journal Article)

Chemical References

• Gentamicins
• Sisomicin

Topics

• Adult
• Aged
• Bacterial Infections (drug therapy, microbiology)
• Drug Evaluation
• Female
• Gentamicins (therapeutic use)
• Humans
• Injections, Intramuscular
• Male
• Middle Aged
• Respiratory Tract Infections (drug therapy, microbiology)
• Sisomicin (administration & dosage, adverse effects, therapeutic use)