Serum desialylated
glycoprotein livel of cirrhotic patients was determined and a diagnostically significant elevation of these
proteins was observed. The level of these patients was usually 2--10 times of that seen in normal subjects and the elevation was signifi-ant (p less than 0.001) when compared to the level in patients with chronic aggressive
hepatitis, severe (2B). Serial determinations of these
proteins in the cirrhotic patients showed no correlation between them and
SGPT as a whole but in several cases in which
SGPT fluctuated the former associated with the latter. In patients with decompensated cirrhotic liver these
proteins returned nearly to the level of compensated patients when it was improved. The level of these
proteins in cirrhotic patients correlated, not always, with
serum albumin (r = -0.46, p less than 0.02) and
indocyanine green clearance rate (r = -0.73, p less than 0.05), but not with
SGPT as well as the other liver function tests.