Cytochalasin B inhibition of endothelial proliferation at wound edges in vitro.

Abstract

Cytochalasin B prevents both migration and wound-associated replication when applied to wounded monolayers of bovine endothelium in tissue culture. The normal low background rate of replication in undisturbed areas of the cultures is not inhibited by cytochalasin B. These results suggest that some form of movement may be required for initiation of wound-associated replication by endothelial cells.

• Authors: S C Selden 3rd, S M Schwartz
• Journal: The Journal of cell biology (J Cell Biol) Vol. 81 Issue 2 Pg. 348-54 (May 1979) ISSN: 0021-9525 [Print] United States
• PMID: 468908 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cytochalasin B
• DNA

Topics

• Animals
• Aorta
• Cattle
• Cell Line
• Cell Movement (drug effects)
• Cytochalasin B (pharmacology)
• DNA (biosynthesis)
• Dose-Response Relationship, Drug
• Endothelium (drug effects, physiology)
• Mitosis (drug effects)
• Wound Healing (drug effects)