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Vasculitis and Sjögren's syndrome with IgA-IgG cryoglobulinemia terminating in immunoblastic sarcoma.

Abstract
Generalized lymphadenopathy and other manifestations of Sjögren's syndrome developed in a 68 year old woman with a long history of systemic vasculitis and arthralgia. An unusual immunologic feature was hypogammaglobulinemia and immunoglobulin A (IgA) monoclonal immunoglobulinemia with mixed IgA-IgG cryoglobulin. At autopsy, the histopathologic findings were compatible with immunoblastic sarcoma. The monoclonal IgA protein, found in serum, pleural and pericardial fluids, showed rheumatoid factor activity. Immunocytes from the immunoblastic sarcoma were found to be the source of the monoclonal IgA protein.
AuthorsY Aizawa, Z A Zawadzki, T S Micolonghi, J W McDowell, R S Neiman
JournalThe American journal of medicine (Am J Med) Vol. 67 Issue 1 Pg. 160-6 (Jul 1979) ISSN: 0002-9343 [Print] United States
PMID463909 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Cryoglobulins
  • Immunoglobulin A
  • Immunoglobulin G
  • Rheumatoid Factor
Topics
  • Aged
  • Body Fluids (immunology)
  • Cryoglobulins
  • Female
  • Humans
  • Immunoglobulin A
  • Immunoglobulin G
  • Lymph Nodes (pathology)
  • Lymphoproliferative Disorders (etiology, immunology, pathology)
  • Paraproteinemias (complications, immunology)
  • Rheumatoid Factor (metabolism)
  • Sjogren's Syndrome (complications, immunology)
  • Vasculitis (complications, immunology, pathology)

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