Prophylactic activity of a phenanthrene methanol (WR 33063) and a quinoline methanol (WR 30090) in human malaria.

Abstract

WR 33063 (3-bromo-10-[alpha-hydroxy-beta-(n, n-diheptylamino)ethyl]-phenanthrene hydrochloride) and WR 30090 (6,8-dichloro-2,3,4-dichlorphenyl-di-n-butylaminoethyl-4- quinolinemethanol hydrochloride) were tested for suppressive prophylactic effect on induced malaria in nonimmune volunteers living in an area where malaria is not naturally transmitted. Doses of 800 mg of WR 33063 and 690 or 460 mg of WR 30090 were given at weekly intervals to men exposed on the day of the first dose to mosquitoes heavily infected with chloroquine- and pyrimethamine-resistant strains of Plasmodium falciparum. WR 33063 did not interfere with early development of infection, but WR 30090 given for 8 weeks provided suppressive cures in 20 of 26 men. P. vivax infections similarly induced broke through WR 30090 treatment in 4 of 15 men, and most of the remainder experienced malaria after completion of the prophylactic course. No side effects of treatment were observed.

• Authors: D F Clyde, V C McCarthy, C C Rebert, R M Miller
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 3 Issue 2 Pg. 220-3 (Feb 1973) ISSN: 0066-4804 [Print] United States
• PMID: 4597716 (Publication Type: Journal Article)

Chemical References

• Antimalarials
• Butylamines
• Methylamines
• Phenanthrenes
• Quinolines
• Methanol

Topics

• Antimalarials (therapeutic use)
• Butylamines (therapeutic use)
• Humans
• Indonesia
• Malaria (prevention & control)
• Methanol (therapeutic use)
• Methylamines (therapeutic use)
• Phenanthrenes (therapeutic use)
• Philippines
• Plasmodium falciparum (classification)
• Plasmodium vivax (classification)
• Quinolines (therapeutic use)
• Vietnam