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Tranexamic acid in control of haemorrhage after dental extraction in haemophilia and Christmas disease.

Abstract
In a double-blind trial tranexamic acid (AMCA, Cyclokapron), 1 g three times a day for five days, significantly reduced blood loss and transfusion requirements after dental extraction in patients with haemophilia and Christmas disease. No side effects were seen in either group of patients. Screening tests showed no toxic action of tranexamic acid on the liver, kidney, or heart.
AuthorsC D Forbes, R D Barr, G Reid, C Thomson, C R Prentice, G P McNicol, A S Douglas
JournalBritish medical journal (Br Med J) Vol. 2 Issue 5809 Pg. 311-3 (May 06 1972) ISSN: 0007-1447 [Print] England
PMID4553818 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Antifibrinolytic Agents
  • Chromium Isotopes
  • Cyclohexanecarboxylic Acids
  • Urea
  • Fibrinogen
Topics
  • Adolescent
  • Adult
  • Aged
  • Antifibrinolytic Agents (therapeutic use)
  • Blood Sedimentation
  • Chromium Isotopes
  • Clinical Trials as Topic
  • Cyclohexanecarboxylic Acids (therapeutic use)
  • Fibrinogen (analysis)
  • Heart Function Tests
  • Hemophilia A
  • Hemophilia B
  • Humans
  • Kidney Function Tests
  • Liver Function Tests
  • Middle Aged
  • Oral Hemorrhage (prevention & control)
  • Tooth Extraction (adverse effects)
  • Urea (blood)

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