Abstract |
In a double-blind trial tranexamic acid ( AMCA, Cyclokapron), 1 g three times a day for five days, significantly reduced blood loss and transfusion requirements after dental extraction in patients with haemophilia and Christmas disease. No side effects were seen in either group of patients. Screening tests showed no toxic action of tranexamic acid on the liver, kidney, or heart.
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Authors | C D Forbes, R D Barr, G Reid, C Thomson, C R Prentice, G P McNicol, A S Douglas |
Journal | British medical journal
(Br Med J)
Vol. 2
Issue 5809
Pg. 311-3
(May 06 1972)
ISSN: 0007-1447 [Print] England |
PMID | 4553818
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antifibrinolytic Agents
- Chromium Isotopes
- Cyclohexanecarboxylic Acids
- Urea
- Fibrinogen
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Topics |
- Adolescent
- Adult
- Aged
- Antifibrinolytic Agents
(therapeutic use)
- Blood Sedimentation
- Chromium Isotopes
- Clinical Trials as Topic
- Cyclohexanecarboxylic Acids
(therapeutic use)
- Fibrinogen
(analysis)
- Heart Function Tests
- Hemophilia A
- Hemophilia B
- Humans
- Kidney Function Tests
- Liver Function Tests
- Middle Aged
- Oral Hemorrhage
(prevention & control)
- Tooth Extraction
(adverse effects)
- Urea
(blood)
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