[Activities of dehydrogenases of the pentose phosphate pathway and transketolase in transplanted mouse hepatomas with different growth rates and in organs of tumor carriers].

Abstract

The activities of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and transketolase were studied in the cytoplasmic fractions of transplanted mouse hepatomas differing in their growth rates, and in the liver, spleen and cortical layer of kidneys of tumour carriers and normal mice. It was shown that transplantation of hepatomas changes the activity of the pentose phosphate pathway enzymes in tumour carrier tissues unaffected by neoplasm. Deviations from normalcy were mainly similar to those observed in the hepatomas. The changes in the enzymatic activities were especially well-pronounced in the mice having rapidly growing hepatomas. This may be due to a generalized effect of the tumour on the organism, which is concurrent with malignancy.

• Authors: R V Birk, V S Shapot
• Journal: Biokhimiia (Moscow, Russia) (Biokhimiia) Vol. 44 Issue 5 Pg. 892-6 (May 1979) ISSN: 0320-9725 [Print] Russia (Federation)
• Vernacular Title: Aktivnost' degidrogenaz pentoznogo puti prevrashcheniia uglevodov i transketolazy v transplantiruemykh gepatomakh mysheĭ s razlichnoĭ skorost'iu rosta i v organakh opukholenositelia.
• PMID: 454718 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Phosphogluconate Dehydrogenase
• Glucosephosphate Dehydrogenase
• Transketolase

Topics

• Animals
• Glucosephosphate Dehydrogenase (metabolism)
• Kidney Cortex (enzymology)
• Liver (enzymology)
• Liver Neoplasms, Experimental (enzymology, physiopathology)
• Male
• Mice
• Neoplasm Transplantation
• Organ Specificity
• Phosphogluconate Dehydrogenase (metabolism)
• Spleen (enzymology)
• Transketolase (metabolism)