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Hypouricaemia and proximal renal tubular dysfunction in acute myeloid leukaemia.

Abstract
Two patients with acute myeloid leukaemia developed hypouricaemia during the period of their illness. Renal clearance studies showed that the hypouricaemia was associated with an increased urate clearance, renal aminoaciduria, and an episodic increase in phosphate clearance. These findings together with an inadequate suppression of urinary urate exceretion after the administration of pyrazinamide suggest proximal tubular dysfunction affecting reabsorption of a wide variety of substances. Ten more patients with acute leukaemia were studied and the results indicate that this lesion develops in a large proportion of patients with acute myeloid leukaemia.
AuthorsM A Mir, I W Delamore
JournalBritish medical journal (Br Med J) Vol. 3 Issue 5934 Pg. 775-7 (Sep 28 1974) ISSN: 0007-1447 [Print] England
PMID4528597 (Publication Type: Journal Article)
Chemical References
  • Amino Acids
  • Phosphates
  • Cytarabine
  • Uric Acid
  • Phosphorus
  • Pyrazinamide
  • Creatinine
  • Muramidase
  • Calcium
  • Daunorubicin
Topics
  • Amino Acids (urine)
  • Calcium (blood)
  • Creatinine (blood)
  • Cytarabine (therapeutic use)
  • Daunorubicin (therapeutic use)
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Kidney Diseases (diagnosis, etiology)
  • Kidney Tubules, Proximal
  • Leukemia, Myeloid, Acute (blood, complications, drug therapy)
  • Middle Aged
  • Muramidase (analysis)
  • Phosphates (metabolism)
  • Phosphorus (blood)
  • Pyrazinamide
  • Uric Acid (blood)

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