Oxandrolone therapy in patients with Turner syndrome.

Abstract

Long-term, low-dosage androgen treatment of patients with Turner syndrome results in more rapid growth and significantly greater adult height than in control patients who receive only estrogen for pubertal development. Seventeen patients treated with oxandrolone for one year and ten treated for two years had significantly greater growth velocities during than before treatment. Mean adult height of 25 patients treated with oxandrolone, fluoxymesterone, or both was significantly taller than the height of adult patients with Turner syndrome treated with estrogen only. Excessive skeletal maturation was not generally observed.

• Authors: M D Urban, P A Lee, J P Dorst, L P Plotnick, C J Migeon
• Journal: The Journal of pediatrics (J Pediatr) Vol. 94 Issue 5 Pg. 823-7 (May 1979) ISSN: 0022-3476 [Print] United States
• PMID: 448501 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Oxandrolone
• Fluoxymesterone

Topics

• Body Height (drug effects)
• Bone and Bones (drug effects)
• Drug Administration Schedule
• Drug Therapy, Combination
• Fluoxymesterone (administration & dosage, pharmacology, therapeutic use)
• Growth (drug effects)
• Humans
• Karyotyping
• Mosaicism
• Oxandrolone (administration & dosage, pharmacology, therapeutic use)
• Retrospective Studies
• Turner Syndrome (drug therapy)