[Pharmacokinetics and clinical studies on CS-1170 (author's transl)].

Abstract

The authors have carried out the pharmacokinetics and clinical studies of CS-1170. The results were as follows; CS-1170 was given by drip infusion for 1 hour dose of 20 mg per kg body weight to 3 children. The maximum blood level was reached at one hour after drip infusion. This blood levels were 38 micrograms/ml, 68 micrograms/ml and 86 micrograms/ml, respectively, (mean 64 micrograms/ml), and level at 2 hours, 11.5 micrograms/ml, 9.4 micrograms/ml, 16 micrograms/ml respectively, (mean 12.3 micrograms/ml), the blood level at 6 hours was not determined. The urinary excretion rates were 94.8 approximately 96.8% up to 6 hours after drip infusion dose of 20 mg per kg body weight. CS-1170 was effective in 7 of 8 cases with pediatric bacterial infections. An ineffective case was a pneumonia due to Serratia marcescens. No side effect was observed except for 2 cases with diarrhea and one case with elevation of GOT and GPT.

• Authors: T Nishimura, Y Kotani, T Takashima, K Hiromatsu
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 32 Issue 2 Pg. 221-6 (Feb 1979) ISSN: 0368-2781 [Print] Japan
• PMID: 439393 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Cephalosporins
• Cephamycins

Topics

• Adolescent
• Age Factors
• Bacterial Infections (drug therapy)
• Cephalosporins (metabolism)
• Cephamycins (adverse effects, metabolism, therapeutic use)
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Kinetics
• Male