Hyporeactivity of infection: potential limitation to therapeutic use of interferon-inducing agents.

Abstract

Interferon inducers are generally most effective as antiviral agents when used prophylactically. One possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. Such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosinic-cytidylic acid, Tilorone hydrochloride, New-castle disease virus, or a strain of encephalomyocarditis virus) during the course of a model picornavirus infection in mice.

• Authors: D A Stringfellow, L A Glasgow
• Journal: Infection and immunity (Infect Immun) Vol. 6 Issue 5 Pg. 743-7 (Nov 1972) ISSN: 0019-9567 [Print] United States
• PMID: 4344367 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Interferon Inducers
• Interferons
• Poly I-C

Topics

• Animals
• Antiviral Agents (therapeutic use)
• Fibroblasts (microbiology)
• Interferon Inducers (therapeutic use)
• Interferons (blood)
• L Cells
• Mice
• Newcastle disease virus (immunology)
• Poly I-C (pharmacology)
• Vesicular stomatitis Indiana virus (immunology)
• Viral Plaque Assay