Abstract |
Continuous infusions of gentamicin, amikacin or sisomicin combined with carbenicillin were compared in a randomized study in the treatment of 572 febrile episodes in 281 patients with cancer. The three treatments (C+A, C+A and C+S) were equally effective with no significant differences in response rate overall (67%, 68%, 67%) or in any infection, except septicemia where C+G had a significantly lower response rate than the other two groups. Pneumonia, the most common infection, had the lowest response rate for all three groups (45-50%). Klebsiella spp. were the most common pathogens and showed a lower response rate than other gram-negative bacilli (P = 0.003). Patients with persistent severe neutropenia had a response rate of 56%. Azotemia was significantly less common in patients with documented infection treated with C+A than in the C+S group. Combinations of carbenicillin plus an aminoglycoside antibiotic are effective for the treatment of infections in neutropenic patients.
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Authors | M J Keating, G P Bodey, M Valdivieso, V Rodriguez |
Journal | Medicine
(Medicine (Baltimore))
Vol. 58
Issue 2
Pg. 159-70
(Mar 1979)
ISSN: 0025-7974 [Print] United States |
PMID | 431401
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Gentamicins
- Kanamycin
- Amikacin
- Carbenicillin
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Topics |
- Adolescent
- Adult
- Aged
- Amikacin
(adverse effects, therapeutic use)
- Bacterial Infections
(complications, drug therapy)
- Carbenicillin
(therapeutic use)
- Drug Therapy, Combination
- Female
- Gentamicins
(adverse effects, therapeutic use)
- Humans
- Infusions, Parenteral
- Kanamycin
(analogs & derivatives)
- Kidney
(drug effects)
- Male
- Middle Aged
- Neoplasms
(complications)
- Neutropenia
(complications)
- Uremia
(complications)
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