A cytoplasmically transmitted, diet-dependent difference in response to the teratogenic effects of 6-aminonicotinamide.

Abstract

The frequency of congenital cleft palate produced by maternal treatment with 6-aminonicotinamide during pregnancy is lower in the C57BL/6J than in the A/J inbred mouse strain. In the C57BL/6J strain the frequency is lower when the mothers are maintained on Purina Lab Chow than when they are on Breeder Chow. A/J females do not show this effect of diet. There is a matroclinous reciprocal cross difference in frequency of induced cleft palate which persists in the back-cross when the F(1) mothers are maintained on Lab Chow but not on Breeder Chow.

• Authors: A C Verrusio, D R Pollard, F C Fraser
• Journal: Science (New York, N.Y.) (Science) Vol. 160 Issue 3824 Pg. 206-7 (Apr 12 1968) ISSN: 0036-8075 [Print] United States
• PMID: 4230607 (Publication Type: Journal Article)

Chemical References

• Niacinamide

Topics

• Abnormalities, Drug-Induced
• Animals
• Cleft Palate (chemically induced)
• Diet
• Extrachromosomal Inheritance
• Female
• Hybridization, Genetic
• Inbreeding
• Maternal-Fetal Exchange
• Mice
• Niacinamide (toxicity)
• Pregnancy
• Pregnancy, Animal