Activity of two chlorinated lincomycin analogues against chloroquine-resistant falciparum malaria in owl monkeys.

Abstract

The chloroquine-resistant Oak Knoll strain of Plasmodium falciparum, recently adapted to the owl monkey (Aotus trivirgatus), was insusceptible to chloroquine therapy. Two chlorinated lincomycin analogues tested in this host-parasite system cured blood-induced infections. Acute infections were treated orally for 7 consecutive days with either 15 or 75 mg of clindamycin hydrochloride (U-21) per kg per day, 10 or 50 mg of N-demethyl-4'-pentyl clindamycin hydrochloride (U-24) per kg per day, or 20 mg of chloroquine base per kg per day. These lincomycin analogues cleared trophozoites from the peripheral blood by the end of the 7-day treatment period. The speed of clearance of parasites was not dose-related, but curative activity appeared dependent upon the amount of drug given as well as the number of daily treatments. The efficacy of U-21 and U-24 is of particular interest since they represent major structural departures from compounds commonly used in the treatment of malaria.

• Authors: K G Powers, R L Jacobs
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 1 Issue 1 Pg. 49-53 (Jan 1972) ISSN: 0066-4804 [Print] United States
• PMID: 4207758 (Publication Type: Journal Article)

Chemical References

• Chlorine
• Chloroquine
• Lincomycin

Topics

• Animals
• Chlorine (therapeutic use)
• Chloroquine (therapeutic use)
• Drug Resistance
• Haplorhini
• Lincomycin (therapeutic use)
• Malaria (drug therapy)
• Plasmodium falciparum
• Time Factors