The effect of iron and protein deficiency on the development of acquired resistance to reinfection with Nippostrongylus brasiliensis in rats.

Abstract

Iron and protein deficiency delays the immunological rejection of Nippostrongylus brasiliensis from the small intestine of rats undergoing a primary infection with the parasite. In the present study, iron and protein deficiency significantly reduced acquired resistance to reinfection with N. brasiliensis. Repletion of deficient animals with iron and protein restored their capacity to mount an effective immune response to a secondary infection with the parasite. These results suggest that chemotherapy of helminthiasis should be integrated with nutritional supplementation.

• Authors: V M Duncombe, T D Bolin, A Davis, J D Kelly
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 32 Issue 3 Pg. 553-8 (Mar 1979) ISSN: 0002-9165 [Print] United States
• PMID: 420147 (Publication Type: Journal Article)

Topics

• Animals
• Hookworm Infections (complications, immunology)
• Iron Deficiencies
• Nippostrongylus (pathogenicity)
• Protein Deficiency (complications, immunology, therapy)
• Rats