[The problem of infections in acute leukemias: origin, therapy and prevention by protective isolation].

Abstract

The most important factors of infection in leukemic patients and immunodepressive effect of chemotherapy are evaluated. The microorganisms causing infections most frequently are considered. The associations of antibiotics for therapy of severe infections are reported. The employement of granulocyte transfusion, in patients with severe neutropenia and infections antibiotico-resistents, is also considered. Dealing with patients liable of infections the possibility of infection prevention and therapy in protected environment is faced. 12 patients affected by acute nonlymphocitic leukemia were treated with cytostatic drugs to induce remission in laminar air flow room. The number of infections is significantly decreased in comparison with of patients treated in open ward. In protected environment it is possible to treat patients with the maximal dose of antiblastic drugs without interruption obtaining higher number of complete remission.

• Authors: R Delsignore, M C Baroni, V Rizzoli, F Quaini, L Mangoni, U Butturini
• Journal: L'Ateneo parmense. Acta bio-medica : organo della Societa di medicina e scienze naturali di Parma (Ateneo Parmense Acta Biomed) Vol. 48 Issue 5 Pg. 381-403 ( 1977) ISSN: 1123-7325 [Print] Italy
• Vernacular Title: Il problema delle infezioni nelle leucosi acute: origine, terapia e prevenzione mediante isolamento protettivo.
• PMID: 418788 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Antineoplastic Agents

Topics

• Anti-Bacterial Agents (therapeutic use)
• Antineoplastic Agents (adverse effects, therapeutic use)
• Drug Resistance, Microbial
• Humans
• Infection Control
• Infections (drug therapy, etiology)
• Leukemia (complications, drug therapy)
• Patient Isolation