Reduced dose of Rho(D) immune globulin following induced first-trimester abortion.

Abstract

A double-blind study of women after first-trimester abortion supports the efficacy of low-dose Rho(D) immune globulin (human) in the prevention of Rh sensitization. Twenty-seven per cent of patients demonstrated a fetomaternal blood leak based on Kleihauer-Betke stains. In follow-up testing, the percentage of positive titers and the absolute titer of detectable antibody at various intervals were related to the dose of administered immune globulin. This study confirmed the possible risk of sensitization in Rh-negative postabortal women and suggests the practical use of single low-dose immune globulin preparations in prevention.

• Authors: P A Hensleigh, W Leslie, E Dixon, E Hall, D Z Kitay, J E Jackson
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 129 Issue 4 Pg. 413-6 (Oct 15 1977) ISSN: 0002-9378 [Print] United States
• PMID: 410298 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Antibodies
• Immunoglobulins
• Rh-Hr Blood-Group System

Topics

• Abortion, Induced
• Antibodies (analysis)
• Antibody Formation
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Humans
• Immunoglobulins (administration & dosage, therapeutic use)
• Pregnancy
• Pregnancy Trimester, First
• Rh-Hr Blood-Group System