The effects of methaqualone on the seizure susceptibility of mice.

Abstract

Methaqualone produces dose- and time-dependent decreases in susceptibility to electrically, chemically, and sound-induced seizures. The antagonism of methaqualone to electroconvulsive shock can be dissociated from its effects on temperature regulation and plasma corticosterone. Studies with SKF525A, a drug known to block enzymes in the liver that metabolize drugs, suggest that methaqualone, rather than a metabolite produced in the liver, is responsible for its anticonvulsant effects. Tolerance to the anticonvulsant effects of methaqualone is also demonstrated.

• Authors: W O Boggan, J S Meyer, R M Steinberg, C Worthington
• Journal: Psychopharmacology (Psychopharmacology (Berl)) Vol. 54 Issue 1 Pg. 45-9 (Aug 31 1977) ISSN: 0033-3158 [Print] Germany
• PMID: 410059 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anticonvulsants
• Methaqualone
• Proadifen
• Corticosterone
• Pentylenetetrazole

Topics

• Acoustic Stimulation
• Animals
• Anticonvulsants
• Body Temperature (drug effects)
• Corticosterone (blood)
• Drug Tolerance
• Electroshock
• Methaqualone (pharmacology)
• Mice
• Mice, Inbred C57BL
• Mice, Inbred DBA
• Pentylenetetrazole (antagonists & inhibitors)
• Proadifen (pharmacology)