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Accumulation of orthochromatophilic normoblasts in bone marrow of vitamin E-deficient monkey, Macaca fasicularis.

Abstract
Crab-eating monkeys, Macaca fasicularis, fed a vitamin E-depleted diet for over 15 months, showed signs of anemia manifested by a lowering in hematocrit, hemoglobin concentration and red blood cell number, and by an increased susceptibility of erythrocytes to hydrogen peroxide lysis. Bone marrow pictures indicated the presence of multinucleated erythroid precursor cells and an accumulation of orthochromatophilic normoblasts. Supplementation with vitamin E resulted in reticulocytosis and a return of the normal bone marrow picture.
AuthorsR Santiyanont, C Yaipimol, P Wilairat
JournalThe Journal of nutrition (J Nutr) Vol. 107 Issue 11 Pg. 2026-30 (Nov 1977) ISSN: 0022-3166 [Print] United States
PMID409814 (Publication Type: Journal Article)
Topics
  • Anemia (etiology)
  • Animals
  • Bone Marrow (pathology)
  • Bone Marrow Diseases (etiology, pathology)
  • Cell Count
  • Cell Differentiation
  • Haplorhini
  • Macaca fascicularis
  • Vitamin E Deficiency (complications, pathology)

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