Treatment of respiratory tract infections with a combination of amoxycillin and clavulanic acid.

Abstract

Forty-four patients with respiratory tract infections were treated using a new formulation of amoxycillin and clavulanic acid. Clinical diagnosis was classified as follows: 19 cases of acute exacerbations of chronic bronchitis, 10 cases of bronchiectasis, and 15 cases of diffuse or localized pneumonia. Amoxycillin/clavulanic acid combination (amoxycillin 250 mg + clavulanic acid 125 mg per tablet) was administered as 2 tablets three times per day for 7-14 days. The efficacy was as follows: chronic bronchitis 94.7%, bronchiectasis 80.0% and pneumonia 93.3%. No severe adverse reactions occurred in treated patients and no renal, hepatic or hematological toxicity was observed. Amoxycillin/clavulanic acid combination was a safe and effective antimicrobial agent for the treatment of respiratory tract infections.

• Authors: G N Karachalios
• Journal: International journal of clinical pharmacology, therapy, and toxicology (Int J Clin Pharmacol Ther Toxicol) Vol. 23 Issue 12 Pg. 647-9 (Dec 1985) ISSN: 0174-4879 [Print] Germany
• PMID: 4093205 (Publication Type: Journal Article)

Chemical References

• Clavulanic Acids
• Clavulanic Acid
• Amoxicillin

Topics

• Adult
• Aged
• Amoxicillin (adverse effects, therapeutic use)
• Clavulanic Acid
• Clavulanic Acids (adverse effects, therapeutic use)
• Drug Therapy, Combination
• Female
• Humans
• Male
• Middle Aged
• Respiratory Tract Infections (drug therapy)