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Comparison of erythromycin base and estolate in gonococcal urethritis.

Abstract
A randomized double-blind trial of 152 men with gonococcal urethritis compared the therapeutic efficacy of erythromycin estolate and erythromycin base. Twenty-one of 86 (24%) men treated with the estolate and 15 of 66 (23%) treated with the base had recurrent or persistent gonococcal infection when seen after a 9-g course of erythromycin. The serum erythromycin activity among estolate-treated patients (3.57 +/- 0.84 microgram/ml) was nearly twice that for base-treated patients (1.76 +/- 0.80 microgram/ml). Our findings do not support routine use of erythromycin for treatment of pregnant, penicillin-allergic patients.
AuthorsS T Brown, H B Pedersen, K K Holmes
JournalJAMA (JAMA) Vol. 238 Issue 13 Pg. 1371-3 (Sep 26 1977) ISSN: 0098-7484 [Print] United States
PMID408522 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Erythromycin
  • Erythromycin Estolate
Topics
  • Clinical Trials as Topic
  • Erythromycin (analogs & derivatives, pharmacology, therapeutic use)
  • Erythromycin Estolate (blood, pharmacology, therapeutic use)
  • Follow-Up Studies
  • Gonorrhea (complications)
  • Humans
  • Male
  • Nasopharynx (microbiology)
  • Neisseria gonorrhoeae (drug effects, isolation & purification)
  • Urethritis (drug therapy, etiology)

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