A study of the analgesic potency of indoprofen and pentazocine in postoperative pain.

Abstract

The relative potency of intravenous indoprofen and intramuscular pentazocine in postoperative pain was evaluated. Indoprofen was administered in 200- and 400-mg single doses and pentazocine was given in 15- and 30-mg doses. Pain was assessed at different time intervals, and additional medication consumption was recorded, as well as side effects and overall evaluations. An analysis of peak pain intensity difference (PID) has shown a significant dose-effect relationship for both drugs and a potency ratio of 1:7 between indoprofen and pentazocine (mg to mg). Based on the frequency of patients requiring remedication and those reporting total pain relief in at least one instance, the potency ratio of indoprofen:pentazocine was 1:13 and 1:10, respectively. The mean peak PID of the pooled data for both doses of each drug was significantly greater for indoprofen. Intravenous indoprofen 400 mg was ranked the most effective overall.

• Authors: A Sartani, N Papatheodossiou, L Parrinello, V Mandelli
• Journal: Journal of clinical pharmacology (J Clin Pharmacol) 1985 Nov-Dec Vol. 25 Issue 8 Pg. 596-600 ISSN: 0091-2700 [Print] England
• PMID: 4078027 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Phenylpropionates
• Indoprofen
• Pentazocine

Topics

• Humans
• Indoprofen (therapeutic use)
• Pain, Postoperative (drug therapy)
• Pentazocine (therapeutic use)
• Phenylpropionates (therapeutic use)
• Random Allocation