Cyclophosphamide-induced remission in Weber-Christian panniculitis.

Abstract

A patient with Weber-Christian panniculitis is described in this report in which treatment with prednisone and hydroxychloroquine caused no improvement of the disease, and even led to a worsening of the symptoms. In contrast, administration of oral cyclophosphamide led to a rapid remission of the disease. As Weber-Christian disease has no known aetiology and no specific treatment has been established, the successful therapy with the cytostatic drug cyclophosphamide may shed light on the pathogenesis of Weber-Christian panniculitis.

• Authors: W Kirch, U Dührsen, H Hoensch, E Ohnhaus
• Journal: Rheumatology international (Rheumatol Int) Vol. 5 Issue 5 Pg. 239-40 ( 1985) ISSN: 0172-8172 [Print] Germany
• PMID: 4070926 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hydroxychloroquine
• Cyclophosphamide
• Prednisone

Topics

• Adult
• Cyclophosphamide (therapeutic use)
• Humans
• Hydroxychloroquine (therapeutic use)
• Male
• Panniculitis, Nodular Nonsuppurative (drug therapy, etiology)
• Prednisone (therapeutic use)