Abstract |
We have evaluated the relationships between adipose tissue lipoprotein-lipase activity (AT-LPL) or post- heparin plasma lipolytic activity (PHLA) and the composition of circulating lipoproteins in 7 patients with multiple symmetric lipomatosis (MSL). In addition we have investigated the behaviour of serum triglycerides after an oral fat load (1 g triglycerides/kg body weight) in 5 MSL patients and in 5 age and sex matched controls. We found significantly higher values of HDL, HDL2 and HDL3 cholesterol in MSL patients than in controls. Moreover, HDL2/ HDL3 cholesterol ratio was higher in MSL patients than in controls, which indicate a predominant increase in HDL2 subfraction. The mean values of AT-LPL in lipomatous tissue was significantly higher than in control tissue. A positive statistically significant correlation was found between AT-LPL activity and HDL, HDL2 and HDL3 cholesterol values. After the fat load the maximal increments of serum triglyceride levels and the triglyceride areas over 8 and 12 h are lower in MSL patients than in controls; there was an inverse, statistically significant correlation between the total PHLA or the extrahepatic PHLA values and the triglyceride areas after lipid load. We conclude that MSL represents a useful naturally occurring model for the study of the role of AT-LPL in the metabolism of triglyceride-rich lipoproteins and in the clearance of lipoproteins in the post-prandial phase.
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Authors | G Enzi, S Martini, G Baggio, G Baldo, M Digito, A Zanella |
Journal | International journal of obesity
(Int J Obes)
Vol. 9 Suppl 1
Pg. 173-6
( 1985)
England |
PMID | 4066122
(Publication Type: Journal Article)
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Chemical References |
- Dietary Fats
- Lipoproteins
- Lipoproteins, HDL
- Lipoproteins, HDL2
- Lipoproteins, HDL3
- Triglycerides
- high density lipoprotein-1
- Heparin
- Lipoprotein Lipase
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Topics |
- Adipose Tissue
(enzymology)
- Dietary Fats
(administration & dosage)
- Female
- Heparin
- Humans
- Lipolysis
- Lipomatosis
(blood, enzymology)
- Lipoprotein Lipase
(metabolism)
- Lipoproteins
(metabolism)
- Lipoproteins, HDL
(blood)
- Lipoproteins, HDL2
- Lipoproteins, HDL3
- Male
- Middle Aged
- Triglycerides
(blood)
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