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Rickets and osteopetrosis: the osteosclerotic (oc) mouse.

Abstract
A new mouse osteopetrotic mutation, osteosclerosis, has been examined with respect to rickets. These osteopetrotic mice were hypocalcemic and hypophosphatemic, and had greatly thickened epiphyseal plates with abnormalities in matrix vesicles when compared with normal littermates. Such biochemic and morphologic manifestations of rickets in this osteopetrotic mutation may explain the failure of osteosclerotic mice to be cured by transplantation of bone marrow from normal littermates and indicate that vitamin D metabolism and matrix vesicle biochemistry warrant further study.
AuthorsR Banco, M F Seifert, S C Marks Jr, J L McGuire
JournalClinical orthopaedics and related research (Clin Orthop Relat Res) Issue 201 Pg. 238-46 (Dec 1985) ISSN: 0009-921X [Print] United States
PMID4064410 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Phosphorus
  • Calcium
Topics
  • Animals
  • Calcium (blood)
  • Growth Plate (ultrastructure)
  • Mice
  • Mice, Inbred Strains
  • Microscopy, Electron
  • Osteopetrosis (metabolism, pathology)
  • Osteosclerosis (metabolism, pathology)
  • Phosphorus (blood)
  • Rickets (metabolism, pathology)

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