Abstract |
We here examine the role of c-myc in the aetiology of Burkitt's lymphomas. We suggest that c-myc causes cellular clones to become immortal while the deregulation of cell multiplication is the consequence of an altered production and/or structure of immunoglobulin chains caused by the 8-14, 8-2 or 8-22 translocations. Data relative to other immunoproliferative disorders are consistent with the hypothesis that the immunoglobulins play a key role in the regulation of the multiplication of lymphocytic cells.
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Authors | G Morpurgo |
Journal | Journal of theoretical biology
(J Theor Biol)
Vol. 116
Issue 3
Pg. 395-8
(Oct 07 1985)
ISSN: 0022-5193 [Print] England |
PMID | 4058028
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Burkitt Lymphoma
(etiology, immunology)
- Gene Expression Regulation
- Humans
- Immunoglobulins
(genetics)
- Oncogenes
- Translocation, Genetic
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