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A comparison of oral cefuroxime axetil and oral amoxycillin in lower respiratory tract infections.

Abstract
We assessed oral cefuroxime axetil in an open study of 30 patients with lower respiratory tract infection and then compared oral cefuroxime with oral amoxycillin in a randomized double blind study in a further 40 patients. Satisfactory clinical responses were obtained in 73% of patients receiving cefuroxime axetil 500 mg tid in the open study, and in the comparative study in 71% of patients receiving cefuroxime axetil 500 mg bd, in 60% of patients receiving cefuroxime axetil 500 mg tid and in 63% of patients receiving amoxycillin 500 mg tid. There were no significant differences in response rates between the three regimens in the comparative study. There were no important adverse effects in any of the patients. Oral cefuroxime axetil is safe and effective in the therapy of lower respiratory tract infections.
AuthorsT J Cooper, E Ladusans, P E Williams, V Polychronopoulos, H Gaya, R M Rudd
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 16 Issue 3 Pg. 373-8 (Sep 1985) ISSN: 0305-7453 [Print] England
PMID4055545 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Cephalosporins
  • Amoxicillin
  • Cefuroxime
  • cefuroxime axetil
Topics
  • Administration, Oral
  • Amoxicillin (administration & dosage, therapeutic use)
  • Cefuroxime (administration & dosage, analogs & derivatives, therapeutic use)
  • Cephalosporins
  • Female
  • Humans
  • Male
  • Middle Aged
  • Peak Expiratory Flow Rate
  • Respiratory Tract Infections (drug therapy, microbiology, physiopathology)
  • Sputum (microbiology)

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