Effects of succinylacetone on methyl alpha-D-glucoside uptake by the rat renal tubule.

Abstract

Succinylacetone, a catabolic end-product of tyrosine, is excreted in large quantities in urine from individuals with hereditary tyrosinemia and the Fanconi syndrome. Succinylacetone inhibits rat renal tubular concentrative uptake of the glucose transport analogue, methyl alpha-D-glucoside, in a noncompetitive and reversible fashion. This compound also depresses oxygen consumption by the rat renal tubule without fine structural damage to mitochondria. It is concluded that succinylacetone may be a useful probe in elucidation of the biochemical mechanism underlying the human Fanconi syndrome.

• Authors: K S Roth, P D Spencer, E S Higgins, R F Spencer
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 820 Issue 1 Pg. 140-6 (Oct 24 1985) ISSN: 0006-3002 [Print] Netherlands
• PMID: 4052413 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Heptanoates
• Heptanoic Acids
• Methylglucosides
• Methylglycosides
• succinylacetone
• methylglucoside
• Adenosine Triphosphate

Topics

• Adenosine Triphosphate (metabolism)
• Animals
• Disease Models, Animal
• Fanconi Syndrome (metabolism)
• Heptanoates (pharmacology)
• Heptanoic Acids (pharmacology)
• Kidney Tubules (drug effects, metabolism)
• Kinetics
• Male
• Methylglucosides (metabolism)
• Methylglycosides (metabolism)
• Oxygen Consumption (drug effects)
• Rats
• Rats, Inbred Strains