Efficacy of fenbendazole and cambendazole against Muellerius capillaris in dairy goats.

Two anthelmintics, fenbendazole and cambendazole, were used in an attempt to eliminate Muellerius capillaris infections in a group of 44 goats. During the course of this study (508 days), M capillaris larvae were found in at least one fecal specimen from each of 22 of the 44 goats. All 44 goats were dewormed with fenbendazole (30 mg/kg of body weight) at the onset of this study (day 18). Two additional dewormings with fenbendazole at 4- to 8-week intervals were restricted to the goats that continued to shed M capillaris larvae. On the basis of routine fecal examinations, fenbendazole eliminated M capillaris larvae from the feces of 8 (36%) of these 22 goats. On day 253, cambendazole (60 mg/kg) was given orally to 17 of these 22 goats (2 of the 22 had died and 3 were not available for treatment); 13 of these goats were still shedding M capillaris larvae. Cambendazole eliminated M capillaris larvae from the feces of 10 (77%) of these 13 goats chronically infected with M capillaris.
AuthorsE L Bliss, E C Greiner
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 46 Issue 9 Pg. 1923-5 (Sep 1985) ISSN: 0002-9645 [Print] UNITED STATES
PMID4051297 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Benzimidazoles
  • Cambendazole
  • Fenbendazole
  • Animals
  • Benzimidazoles (therapeutic use)
  • Cambendazole (therapeutic use)
  • Feces (parasitology)
  • Female
  • Fenbendazole (therapeutic use)
  • Goats
  • Larva (isolation & purification)
  • Lung Diseases, Parasitic (drug therapy, parasitology, veterinary)
  • Nematoda (isolation & purification)
  • Nematode Infections (drug therapy, parasitology, veterinary)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: