Radical irradiation and misonidazole in the treatment of advanced cervical carcinoma: results of a phase II trial.

Abstract

Between February 1979 and January 1982, a Phase II study of misonidazole as a radiosensitizer was performed in 34 patients with advanced carcinoma of the uterine cervix. Twenty-nine patients were treated with conventional fractionated radiation and five patients with a twice daily fractionation schedule, 3 days a week. The total dose to the whole pelvis was 5000 cGy delivered in 5.5 weeks. Intracavitary curietherapy delivered an additional boost to the tumor. Misonidazole was given to all patients during external radiation and to 25 patients during intracavitary treatment for a total dose of 11 to 14 g/m2. All patients were followed for at least 28 months after treatment with a median follow-up of 52 months. Misonidazole toxicity included peripheral neuropathy (18%) and central nervous system toxicity (3%). The 3-year survival rate is 74% and the 3-year disease-free survival is 57%. When compared to our historical group survival, 42 and 12% for Stage III and IV, respectively, our data suggest that there is a probable advantage from using misonidazole in advanced carcinoma of the cervix.

• Authors: T Girinski, M H Pejovic, C Haie, M Bonnay, A Gerbaulet, J J Mazeron, E Malaise, D Chassagne
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 11 Issue 10 Pg. 1783-7 (Oct 1985) ISSN: 0360-3016 [Print] United States
• PMID: 4044341 (Publication Type: Journal Article)

Chemical References

• Misonidazole

Topics

• Female
• Humans
• Lymph Nodes (radiation effects)
• Misonidazole (adverse effects, therapeutic use)
• Radiotherapy Dosage
• Uterine Cervical Neoplasms (radiotherapy)