Sicca syndrome in mesangial IgA glomerulonephritis.

Abstract

Schirmer-test, history of conjunctivitis, salivary gland scintigraphy and SSA/SSB (Ro/La) antibodies were evaluated in 24 patients with mesangial IgA glomerulonephritis (IgA-GN), 58 patients with non-IgA-GN and 100 healthy controls. A sicca syndrome (positive Schirmer-test) was found in 46% of patients with IgA-GN and 17% of non-IgA-GN and 8% of controls (p less than 0.001). Only one of the IgA-GN patients volunteered a history of xerosis of the conjunctiva, but upon questioning 17% reported a history of ophthalmological treatment for recurrent conjunctivitis. The observation adds another extrarenal facet to the syndrome of mesangial IgA-GN. Diminished tear production may be another (immune?) abnormality of the oropharyngeal system.

• Authors: K Andrassy, G Lichtenberg, M Rambausek
• Journal: Clinical nephrology (Clin Nephrol) Vol. 24 Issue 2 Pg. 60-2 (Aug 1985) ISSN: 0301-0430 [Print] Germany
• PMID: 4042438 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Female
• Glomerular Mesangium
• Glomerulonephritis, IGA (complications)
• Humans
• Keratoconjunctivitis (complications, immunology)
• Male
• Middle Aged