[Clinical study of the measurement of tissue polypeptide antigen in patients with breast cancer].

Abstract

Tissue polypeptide antigen (TPA) concentrations in patients with breast cancer were measured using a radioimmunoassay (RIA) kit. Although this RIA kit presented some problems in the dilution test of high-concentration samples, it was found to be adequate for clinical use. It was shown that the measurement of serum TPA concentration was useful in monitoring the local recurrence, for the early diagnosis of distant metastasis and for evaluating the therapeutical effect after surgery. TPA concentration showed no correlation with CEA concentration. Therefore, in order to raise the rate of diagnostic success, simultaneous measurement of both TPA and CEA was essential.

• Authors: M Fukunaga, N Otsuka, M Yanagi, T Sone, A Muranaka, S Yanagimoto, T Tomomitsu, R Morita, T Ohama, H Sonoo
• Journal: Gan no rinsho. Japan journal of cancer clinics (Gan No Rinsho) Vol. 31 Issue 8 Pg. 923-8 (Jul 1985) ISSN: 0021-4949 [Print] Japan
• PMID: 4032770 (Publication Type: English Abstract, Journal Article)

Chemical References

• Carcinoembryonic Antigen
• Peptides
• Tissue Polypeptide Antigen

Topics

• Adult
• Aged
• Bone Neoplasms (immunology, secondary)
• Breast Neoplasms (immunology)
• Carcinoembryonic Antigen (analysis)
• Female
• Humans
• Liver Neoplasms (immunology, secondary)
• Lung Neoplasms (immunology, secondary)
• Middle Aged
• Peptides (analysis)
• Radioimmunoassay
• Tissue Polypeptide Antigen